In a multi-year study of 81 adults conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been shown to be sensitive to heightened CSF levels of Aβ and tau. This study examined cerebrospinal fluid (CSF) amyloid β 1-42 (Aβ) and tau levels and performance on a computerized self-administered test battery, the Computer-Administered Neuropsychological Screen for MCI (CANS-MCI). […]
In further analysis from a multi-year study of 81 adults conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been as shown to be predictively sensitive to heightened CSF levels of Aβ and tau. CSF was collected from participants near to the time of completing the baseline Computer- Administered Neuropsychological Screen for MCI (CANS). CSF levels of […]
This page collects in one place scientific literature regarding the CANS-MCI referred to in our other science-related blog posts. The most comprehensive summary of all the science behind the CANS-MCI is contained in the document titled “Scientific Background of the CANS-MCI”. This extracts information from the other literature and discusses the science in depth. Scientific […]
The CANS-MCI was developed to solve a problem: there were no tools available that could accurately and economically detect the cognitive changes most predictive of further abnormal decline in adults and the elderly. The most common type of decline in need of early detection was toward Alzheimer’s disease. The CANS-MCI was designed to measure all […]
Emory Hill, PhD and Jo Anne Laboff, MSW Scores on the CANS-MCI were compared with the results of full neuropsychological examinations that were blind to the CANS-MCI results. Identical analyses were performed using full independent neuropsychological evaluation classifications on the 74 subjects who returned a year later. To determine the ability of the Computer-Administered Neuropsychological […]
Abstract The CANS-MCI, a computer administered, scored, and interpreted touch screen battery, was evaluated for its ability to screen for mild cognitive impairment. 310 community-dwelling elders enrolled in an NIA-funded study. One-month test-retest reliability correlations were all significant (p<.05-p<.001). Concurrent validity correlations were all significant (p<.001). A high level of diagnostic validity was attained relative […]
Automated Primary Care Screeningfor Mild Cognitive Impairment and Alzheimer’s Disease Jane B. Tornatore, PhD[1], Emory Hill, PhD[1] & Kenric W. Hammond, MD[2] POSTERPresented at The 8th International Conference on Alzheimer’s Diseaseand Related Disorders, Stockholm, Sweden 2002. ABSTRACT Background: People with Mild Cognitive Impairment (MCI) appear to develop Alzheimer’s disease (AD) at a rate of 10-15% a year. Since […]
The early detection of cognitive ability changes due to sports concussion is critical because of the increased vulnerability that follows a concussion. According to Harmon et al, “Animal and human studies support the concept of post-concussive vulnerability, showing that a second blow before the brain has recovered results in worsening metabolic changes within the cell. […]
There is a critical and increasing research focus upon developing ways to identify high-risk MCI patients for early treatment. Such efforts depend upon knowing as much as possible about who is most likely to progress from MCI to Alzheimer’s disease. A very recently published study[1] of the most significant predictors of progression from MCI to Alzheimer’s […]
Cognitive testing over the Internet must be performed in controlled environments Until fairly recently, all cognitive ability testing was done by professionals in their offices. It usually went without saying that the person being tested was not distracted, interrupted, or coached by anyone during testing. Recently, the Internet has created the possibility of testing people […]