NIH-funded & validated against full neuropsychological evaluations.
The following neuropsychological tests were used to assess the validity of the CANS-MCI in studies supported by grants from the Veterans Administration and the National Institute on Aging.
- Wechsler Memory Scale-Revised (WMS-R)
- Logical Memory Immediate and Delayed (LMS-I and LMS-II)
- Mattis Dementia Rating Scale (DRS)
- Wechsler Adult Intelligence Scale, Digit Symbol test
- (Later validated against the MOCA and MMSE)
- (Later correlated with CSF amyloid β 1-42 (Aβ) and tau levels)
Research articles are available upon request and much of the same information is summarized below.
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Sensitivity of the CANS-MCI to CSF Markers of Preclinical Alzheimer’s
/in Studies/by Emory HillIn a multi-year study of 81 adults conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been shown to be sensitive to heightened CSF levels of Aβ and tau. This study examined cerebrospinal fluid (CSF) amyloid β 1-42 (Aβ) and tau levels and performance on a computerized self-administered test battery, the Computer-Administered Neuropsychological Screen for MCI (CANS-MCI). […]
Within-session Learning of an Object Identification Task Predicts Elevated Brain Aβ
/in Studies/by Emory HillIn further analysis from a multi-year study of 81 adults conducted by the Kentucky Neuroscience Institute, the CANS-MCI has been as shown to be predictively sensitive to heightened CSF levels of Aβ and tau. CSF was collected from participants near to the time of completing the baseline Computer- Administered Neuropsychological Screen for MCI (CANS). CSF levels of […]
Quick Download Links of Scientific Literature
/in Articles/by Emory HillThis page collects in one place scientific literature regarding the CANS-MCI referred to in our other science-related blog posts. The most comprehensive summary of all the science behind the CANS-MCI is contained in the document titled “Scientific Background of the CANS-MCI”. This extracts information from the other literature and discusses the science in depth. Scientific […]
Scientific Background of the CANS-MCI
/in Studies/by Emory HillThe CANS-MCI was developed to solve a problem: there were no tools available that could accurately and economically detect the cognitive changes most predictive of further abnormal decline in adults and the elderly. The most common type of decline in need of early detection was toward Alzheimer’s disease. The CANS-MCI was designed to measure all […]
The Validity of the CANS-MCI II (2005 – 2014)
/in Articles, Studies/by Emory HillEmory Hill, PhD and Jo Anne Laboff, MSW Scores on the CANS-MCI were compared with the results of full neuropsychological examinations that were blind to the CANS-MCI results. Identical analyses were performed using full independent neuropsychological evaluation classifications on the 74 subjects who returned a year later. To determine the ability of the Computer-Administered Neuropsychological […]
Initial Validation of the CANS-MCI (2005)
/in Articles, Studies/by Emory HillAbstract The CANS-MCI, a computer administered, scored, and interpreted touch screen battery, was evaluated for its ability to screen for mild cognitive impairment. 310 community-dwelling elders enrolled in an NIA-funded study. One-month test-retest reliability correlations were all significant (p<.05-p<.001). Concurrent validity correlations were all significant (p<.001). A high level of diagnostic validity was attained relative […]
International Conference on Alzheimer’s Disease and Related Disorders, 2002
/in Articles, Studies/by Emory HillAutomated Primary Care Screeningfor Mild Cognitive Impairment and Alzheimer’s Disease Jane B. Tornatore, PhD[1], Emory Hill, PhD[1] & Kenric W. Hammond, MD[2] POSTERPresented at The 8th International Conference on Alzheimer’s Diseaseand Related Disorders, Stockholm, Sweden 2002. ABSTRACT Background: People with Mild Cognitive Impairment (MCI) appear to develop Alzheimer’s disease (AD) at a rate of 10-15% a year. Since […]
The CANS-MCI for Concussion Assessment
/in Articles, Opinion/by Emory HillThe early detection of cognitive ability changes due to sports concussion is critical because of the increased vulnerability that follows a concussion. According to Harmon et al, “Animal and human studies support the concept of post-concussive vulnerability, showing that a second blow before the brain has recovered results in worsening metabolic changes within the cell. […]
The CANS-MCI for the Assessment of Alzheimer’s Risk
/in Articles, Studies/by Emory HillThere is a critical and increasing research focus upon developing ways to identify high-risk MCI patients for early treatment. Such efforts depend upon knowing as much as possible about who is most likely to progress from MCI to Alzheimer’s disease. A very recently published study[1] of the most significant predictors of progression from MCI to Alzheimer’s […]
Concerning Cognitive Testing over the Internet
/in Opinion/by Emory HillCognitive testing over the Internet must be performed in controlled environments Until fairly recently, all cognitive ability testing was done by professionals in their offices. It usually went without saying that the person being tested was not distracted, interrupted, or coached by anyone during testing. Recently, the Internet has created the possibility of testing people […]